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PepMix™ ZIKV (E) Ultra (Zika virus)

PepMix™ ZIKV (E) Ultra (Zika virus)
  
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Delivery in 2-5 days
607,00 €
607,00 €

Excluding tax
prices do not include tax. For shipment within Germany 19% MwSt will be included at checkout and in the invoice. For shipment within EU-countries you will need to provide the valid VAT number. International customers should note that all duties, import fees, and taxes are to be paid by the customer
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PepMix™ ZIKV (E) Ultra (Zika virus)

Product Code: PM-ZIKV-E

Pool of 146 15meric peptides derived from Envelope protein E of Zika Virus (ZIKV) designed to cover the full sequence diversity of Zika Virus, used for T cell assays (e.g. ELISPOT). 15 subtypes of Zika Virus polyprotein sequences of were used with our proprietary ULTRA algorithm to obtain peptide combinations providing full coverage of protein variability.
Amount: 1 vial containing 15 nmol (appr. 25µg) per peptide
Purity: >70% (HPLC-MS)
Delivery Format: Freeze dried in amber type glass vial
Application(s): T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication(s)/Topic(s): Infection, ZIKA fever, Mosquito transmission, Microcephaly
Delivery Time: 2 - 5 days

PepMixes™ ZIKV (Zika) Ultra
Zika virus (ZIKV) belongs to the flaviviruses such as dengue virus, West Nile virus and yellow fever virus. Zika virus causes Zika fever or Zika virus disease usually showing no or only mild symptoms. However, ZIKV can also cause microcephaly, severe brain malformations, and other birth defects in unborn babys. To contain a Zika epidemic researchers worldwide are working on vaccine development using peptide tools for screening and immune monitoring such PepMix™ peptide pools and peptide microarrays. We developed a proprietary algorithm to obtain peptide combinations providing optimal coverage of protein variability. Broad coverage of sequence variability provided by these new peptide pools enables stimulation and monitoring of immune responses in patients independent of geographical origin.

Benefits of PepMix™
- Equivalent or better stimulation of CD4+ and CD8+ T-cell responses compared to whole protein antigens
- Simultaneous detection of CD4+ and CD8+ responses in a single sample
- Improved responses in stored blood and PBM cells compared to whole protein antigens
- More reliable as control than phytohemagglutinin (PHA) and concanavalin A (ConA)
- High-batch-to-batch reproducibility
- Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
- Prolonged shelf stability when stored freeze dried

PepMix™ ZIKV (E) Ultra (Zika virus)

References:
Read References with PepMix™ Peptide Pools - Infectious Diseases

Application Notes
"Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy"
Lam et al. (2015) Full text
"The Challenge of Antigen Sequence Diversity: Solutions with ULTRA Peptide Libraries"
Reimer (2016) Full text
"Peptide-Stimulated Expansion of Virus-specific T cells for Preventative Treatment after Allogeneic Stem Cell Transplantation"
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our "go-to" company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

PepMix™ ZIKV (E) Ultra (Zika virus)

 
Code
Product Name
 
Price
Buy
PM-YF-NS4B
PepMix™ Yellow fever (NS4B)
Pool of 60 peptides derived from a peptide scan through Yellow fever Non-structural protein 4B of Yellow fever virus for T cell assays
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PM-ZIKV-C
PepMix™ ZIKV (C) Ultra (Zika virus)
Pool of 48 15meric peptides derived from Capsid protein C of Zika Virus (ZIKV) designed to cover the full sequence diversity of Zika Virus, used for T cell assays (e.g. ELISPOT)
add to cart
PM-ZIKV-E
PepMix™ ZIKV (E) Ultra (Zika virus)
Pool of 146 15meric peptides derived from Envelope protein E of Zika Virus (ZIKV) designed to cover the full sequence diversity of Zika Virus, used for T cell assays (e.g. ELISPOT)
add to cart
PM-ZIKV-M
PepMix™ ZIKV (M) Ultra (Zika virus)
Pool of 49 15meric peptides derived from Membrane glycoprotein M of Zika Virus (ZIKV) designed to cover the full sequence diversity of Zika Virus, used for T cell assays (e.g. E...
add to cart
PM-ZIKV-NS1
PepMix™ ZIKV (NS1) Ultra (Zika virus)
Pool of 166 15meric peptides derived from Nonstructural protein NS1 of Zika Virus (ZIKV) designed to cover the full sequence diversity of Zika Virus, used for T cell assays (e.g...
add to cart
RT-HD-PanFl
RepliTope™ Antigen Collection Pan-Flavivirus Ultra (Zika)
Peptide microarray displaying 6253 peptides derived from selected proteins of ZIKA virus, Dengue virus, West Nile virus, Yellow fever virus and Saint Louis encephalitis virus
add to cart

Description

Product Code: PM-ZIKV-E

Pool of 146 15meric peptides derived from Envelope protein E of Zika Virus (ZIKV) designed to cover the full sequence diversity of Zika Virus, used for T cell assays (e.g. ELISPOT). 15 subtypes of Zika Virus polyprotein sequences of were used with our proprietary ULTRA algorithm to obtain peptide combinations providing full coverage of protein variability.
Amount: 1 vial containing 15 nmol (appr. 25µg) per peptide
Purity: >70% (HPLC-MS)
Delivery Format: Freeze dried in amber type glass vial
Application(s): T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication(s)/Topic(s): Infection, ZIKA fever, Mosquito transmission, Microcephaly
Delivery Time: 2 - 5 days

PepMixes™ ZIKV (Zika) Ultra
Zika virus (ZIKV) belongs to the flaviviruses such as dengue virus, West Nile virus and yellow fever virus. Zika virus causes Zika fever or Zika virus disease usually showing no or only mild symptoms. However, ZIKV can also cause microcephaly, severe brain malformations, and other birth defects in unborn babys. To contain a Zika epidemic researchers worldwide are working on vaccine development using peptide tools for screening and immune monitoring such PepMix™ peptide pools and peptide microarrays. We developed a proprietary algorithm to obtain peptide combinations providing optimal coverage of protein variability. Broad coverage of sequence variability provided by these new peptide pools enables stimulation and monitoring of immune responses in patients independent of geographical origin.

Benefits of PepMix™
- Equivalent or better stimulation of CD4+ and CD8+ T-cell responses compared to whole protein antigens
- Simultaneous detection of CD4+ and CD8+ responses in a single sample
- Improved responses in stored blood and PBM cells compared to whole protein antigens
- More reliable as control than phytohemagglutinin (PHA) and concanavalin A (ConA)
- High-batch-to-batch reproducibility
- Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
- Prolonged shelf stability when stored freeze dried

References

References:
Read References with PepMix™ Peptide Pools - Infectious Diseases

Application Notes
"Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy"
Lam et al. (2015) Full text
"The Challenge of Antigen Sequence Diversity: Solutions with ULTRA Peptide Libraries"
Reimer (2016) Full text
"Peptide-Stimulated Expansion of Virus-specific T cells for Preventative Treatment after Allogeneic Stem Cell Transplantation"
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our "go-to" company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

Documentation

Properties

Related Products

PM-YF-NS4B
PepMix™ Yellow fever (NS4B)
Pool of 60 peptides derived from a peptide scan through Yellow fever Non-structural protein 4B of Yellow fever virus for T cell assays
add to cart
PM-ZIKV-C
PepMix™ ZIKV (C) Ultra (Zika virus)
Pool of 48 15meric peptides derived from Capsid protein C of Zika Virus (ZIKV) designed to cover the full sequence diversity of Zika Virus, used for T cell assays (e.g. ELISPOT)
add to cart
PM-ZIKV-E
PepMix™ ZIKV (E) Ultra (Zika virus)
Pool of 146 15meric peptides derived from Envelope protein E of Zika Virus (ZIKV) designed to cover the full sequence diversity of Zika Virus, used for T cell assays (e.g. ELISPOT)
add to cart
PM-ZIKV-M
PepMix™ ZIKV (M) Ultra (Zika virus)
Pool of 49 15meric peptides derived from Membrane glycoprotein M of Zika Virus (ZIKV) designed to cover the full sequence diversity of Zika Virus, used for T cell assays (e.g. E...
add to cart
PM-ZIKV-NS1
PepMix™ ZIKV (NS1) Ultra (Zika virus)
Pool of 166 15meric peptides derived from Nonstructural protein NS1 of Zika Virus (ZIKV) designed to cover the full sequence diversity of Zika Virus, used for T cell assays (e.g...
add to cart
RT-HD-PanFl
RepliTope™ Antigen Collection Pan-Flavivirus Ultra (Zika)
Peptide microarray displaying 6253 peptides derived from selected proteins of ZIKA virus, Dengue virus, West Nile virus, Yellow fever virus and Saint Louis encephalitis virus
add to cart

Quality Assurance

All production is performed according to ISO 9001:2015 standards.

ISO 9001

 
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Contact us:

JPT Peptide Technologies GmbH
Volmerstrasse 5
12489 Berlin, Germany
Technical Support:
T: +49-30-6392-7878
X: +49-30-6392-7888
e-mail: peptide@jpt.com
USA & Canada:
T: 1.888.JPT.COM0 (1.888.578.2660)
X: 1.888.JPT.COM6 (1.888.578.2666)
e-mail: peptide@jpt.com