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PepMix™ HBV (LEP) Ultra

PepMix™ HBV (LEP) Ultra
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1 $ 520.00
  
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Prices do not include tax. For shipment within Germany 16% MwSt will be included at checkout and in the invoice. For shipment within EU-countries you will need to provide the valid VAT number. International customers should note that all duties, import fees, and taxes are to be paid by the customer
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Invoice - shipping to USA/Canada: 60.00
Credit Card - shipping to USA/Canada: 60.00
PayPal - shipping to USA/Canada: 60.00

PepMix™ HBV (LEP) Ultra

Product Code: PM-HBV-LEPULTRA

Pool of 216 15meric peptides derived from Large envelope protein of HBV designed to cover the high sequence diversity of the Hepatits B virus for T cell assays. All peptide sequences are based on the HBV sequence database (HBVdb, hbvdb.ibcp.fr). We developed a proprietary algorithm to obtain peptide combinations providing an optimal coverage of protein variability. For this PepMix™ the average coverage is 83%.
Amount: 1 vial containing 15 nmol (appr. 25µg) per peptide
Purity: >70% (HPLC-MS)
Delivery Format: Freeze dried in amber type glass vial
Application(s): T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication(s)/Topic(s): Infection, Hepatitis, Liver, Polyarteritis nodosa
Delivery Time: 2-5 days

PepMixes™ ULTRA
Sequence diversity is a hallmark of many pathogenic viruses including HIV, HBV and Influenza. Recent DNA sequencing efforts have revealed similar sequence diversity among eukaryotes. Therefore, sequence variability has to be taken into account for the design of peptide libraries for immune monitoring, immunotherapy or vaccine development. With the new ULTRA concept we are now able to provide peptide libraries that encompass a broad spectrum of sequence diversity. Created with our ULTRA bioinformatics algorithm the peptide libraries are available as PepMix™ Peptide Pools and RepliTope™ Peptide Microarrays.

Benefits of PepMix™
- Equivalent or better stimulation of CD4+ and CD8+ T-cell responses compared to whole protein antigens
- Simultaneous detection of CD4+ and CD8+ responses in a single sample
- Improved responses in stored blood and PBM cells compared to whole protein antigens
- More reliable as control than phytohemagglutinin (PHA) and concanavalin A (ConA)
- High-batch-to-batch reproducibility
- Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
- Prolonged shelf stability when stored freeze dried

PepMix™ HBV (LEP) Ultra

References:
Read References with PepMix™ Peptide Pools - Infectious Diseases

Application Notes
"Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy"
Lam et al. (2015) Full text
"Peptide-stimulated Expansion of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell Transplantation"
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our "go-to" company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

Description

Product Code: PM-HBV-LEPULTRA

Pool of 216 15meric peptides derived from Large envelope protein of HBV designed to cover the high sequence diversity of the Hepatits B virus for T cell assays. All peptide sequences are based on the HBV sequence database (HBVdb, hbvdb.ibcp.fr). We developed a proprietary algorithm to obtain peptide combinations providing an optimal coverage of protein variability. For this PepMix™ the average coverage is 83%.
Amount: 1 vial containing 15 nmol (appr. 25µg) per peptide
Purity: >70% (HPLC-MS)
Delivery Format: Freeze dried in amber type glass vial
Application(s): T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication(s)/Topic(s): Infection, Hepatitis, Liver, Polyarteritis nodosa
Delivery Time: 2-5 days

PepMixes™ ULTRA
Sequence diversity is a hallmark of many pathogenic viruses including HIV, HBV and Influenza. Recent DNA sequencing efforts have revealed similar sequence diversity among eukaryotes. Therefore, sequence variability has to be taken into account for the design of peptide libraries for immune monitoring, immunotherapy or vaccine development. With the new ULTRA concept we are now able to provide peptide libraries that encompass a broad spectrum of sequence diversity. Created with our ULTRA bioinformatics algorithm the peptide libraries are available as PepMix™ Peptide Pools and RepliTope™ Peptide Microarrays.

Benefits of PepMix™
- Equivalent or better stimulation of CD4+ and CD8+ T-cell responses compared to whole protein antigens
- Simultaneous detection of CD4+ and CD8+ responses in a single sample
- Improved responses in stored blood and PBM cells compared to whole protein antigens
- More reliable as control than phytohemagglutinin (PHA) and concanavalin A (ConA)
- High-batch-to-batch reproducibility
- Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
- Prolonged shelf stability when stored freeze dried

References

References:
Read References with PepMix™ Peptide Pools - Infectious Diseases

Application Notes
"Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy"
Lam et al. (2015) Full text
"Peptide-stimulated Expansion of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell Transplantation"
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our "go-to" company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

Documentation

Properties

News

Infectious diseases beyond COVID-19

JPT's peptide formats in the literature
(Oct 2020)
Read more

SARS COV-2 Mass Spec Reference Kit Released!:

SARS-CoV-2 SpikeMix  for Mass Spectrometry covers spike, NCAP, VME-1 & ORF9B
(July 2020)
Read more

New! SARS-CoV-2 Epitope Mapping Peptide Sets

Save time and samples and check our new SARS-CoV-2 Epitope Mapping Peptide Sets (EMPS).
(Apr 2020)
Read more


> Read more news!

Quality Assurance

All production is performed according to ISO 9001:2015 standards.

ISO 9001

 
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Contact us:

JPT Peptide Technologies GmbH
Volmerstrasse 5
12489 Berlin, Germany
Technical Support:
T: +49-30-6392-7878
X: +49-30-6392-7888
e-mail: peptide@jpt.com
USA & Canada:
T: 1.888.JPT.COM0 (1.888.578.2660)
X: 1.888.JPT.COM6 (1.888.578.2666)
e-mail: peptide@jpt.com