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PepMix™ Collection HCMV (2x1ug/peptide)

PepMix™ Collection HCMV (2x1ug/peptide)

  
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Delivery in 2-5 days
660,00 €
660,00 €

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PepMix™ Collection HCMV (2x1ug/peptide)

Product Code: PM-C-HCMV-1

Collection of 19 peptide pools (overlapping peptides scans, 15mers with 11 aa overlap) through 19 immuonodominant antigens of Human cytomegalovirus (HHV-5).
Amount: 2 aliquots of 19 peptide pools containing 1µg per peptide /tube
Purity: >70% (HPLC-MS)
Delivery Format: Freeze dried in micro tube rack with individual vials.
Application(s): T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response, Patient stratification, Qualification of immune responses
Indication(s)/Topic(s): Infection, Control, Cancer, TORCH, Infectious mononucleosis, CMV hepatitis, Retinitis, Colitis, Pneumonitis, Esophagitis, AIDS, Cancer chemotherapy, Transplantation
Delivery Time: 2-5 days

PepMix™ Peptide Pools
The use of complete protein-spanning mixtures of overlapping peptides (PepMix) is extremely efficient for immunostimulation of T-lymphocytes and diagnostic applications. In order to establish reliable and validated T-cell assays such as ELISPOT, appropriate positive and negative controls are essential. Selection of such controls helps to confirm proper functionality of the assay as well as viability of the cells used. In addition, high quality controls are most important to establish standardized assay protocols in clinical setups. Compared to commonly used controls like phytohemagglutinin (PHA) and concanavalin A (ConA) that stimulate T-cells as well as other cell types or full length antigens, synthetic peptide pools offer the advantage of a high batch-to-batch reproducibility, applicability of reliable chemical and biochemical QC/QA measures and shelf stability when stored as freeze dried aliquots.

Benefits of PepMix™
- Equivalent or better stimulation of CD4+ and CD8+ T-cell responses compared to whole protein antigens
- Simultaneous detection of CD4+ and CD8+ responses in a single sample
- Improved responses in stored blood and PBM cells compared to whole protein antigens
- More reliable as control than phytohemagglutinin (PHA) and concanavalin A (ConA)
- High-batch-to-batch reproducibility
- Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
- Prolonged shelf stability when stored freeze dried

PepMix™ Collection HCMV (2x1ug/peptide)

References:
Read References with PepMix™ Peptide Pools - Infectious Diseases

Application Notes
"Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy"
Lam et al. (2015) Full text
"Peptide-stimulated Expansion of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell Transplantation"
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our "go-to" company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

PepMix™ Collection HCMV (2x1ug/peptide)

 
Code
Product Name
 
Price
Buy
PM-IE1
PepMix™ HCMVA (IE-1)
Positive Control Pool of 120 peptides derived from a peptide scan through 55 kDa immediate-early protein 1 (IE-1) of Human cytomegalovirus (HHV-5)
add to cart
PM-IE2
PepMix™ HCMVA (IE-2)
Positive Control Pool of 143 peptides derived from a peptide scan through 45 kDa immediate-early protein 2 (IE-2) of Human cytomegalovirus (HHV-5).
add to cart
PM-PP65-2
PepMix™ HCMVA (pp65) (>90%)
Positive Control Pool of 138 peptides derived from a peptide scan through 65 kDa phosphoprotein (pp65) of Human cytomegalovirus (HHV-5)
add to cart
PM-UL103
PepMix™ HCMVA (UL103)
Pool of 60 peptides derived from a peptide scan through Protein UL103 of Human cytomegalovirus (HHV-5) for T cell assays (e.g. ELISPOT)
add to cart
PM-UL151
PepMix™ HCMVA (UL151)
Pool of 82 peptides derived from a peptide scan through Orf UL151 of Human cytomegalovirus (HHV-5) for T cell assays (e.g. ELISPOT)
add to cart
PM-UL153
PepMix™ HCMVA (UL153)
Pool of 67 peptides derived from a peptide scan through Orf UL153 of Human cytomegalovirus (HHV-5) for T cell assays (e.g. ELISPOT)
add to cart
PM-UL28
PepMix™ HCMVA (UL28)
Pool of 92 peptides derived from a peptide scan through Uncharacterized protein UL28 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL36
PepMix™ HCMVA (UL36)
Pool of 117 peptides derived from a peptide scan through Uncharacterized protein UL36 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL40
PepMix™ HCMVA (UL40)
Pool of 53 peptides derived from a peptide scan through Uncharacterized protein UL40 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL48
PepMix™ HCMVA (UL48)_ 2 subpools
Pool of 2 x 281 peptides derived from a peptide scan through Deneddylase UL48 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL55
PepMix™ HCMVA (UL55)
Pool of 224 peptides derived from a peptide scan through Envelope glycoprotein B (UL55) of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL82
PepMix™ HCMVA (UL82)
Pool of 137 peptides derived from a peptide scan through 71 kDa phosphoprotein (UL82) of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL94
PepMix™ HCMVA (UL94)
Pool of 84 peptides derived from a peptide scan through Capsid-binding protein UL94 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL99
PepMix™ HCMVA (UL99)
Pool of 45 peptides derived from a peptide scan through Tegument protein UL99 of Human cytomegalovirus (HHV-5) for T cell assays (e.g. ELISPOT)
add to cart
PM-US24
PepMix™ HCMVA (US24)
Pool of 123 peptides derived from a peptide scan through Tegument protein US24 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-US29
PepMix™ HCMVA (US29)
Pool of 113 peptides derived from a peptide scan through Uncharacterized protein HHRF4 (US29) of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-US3
PepMix™ HCMVA (US3)
Pool of 44 peptides derived from a peptide scan through Unique short US3 glycoprotein of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-US32
PepMix™ HCMVA (US32)
Pool of 43 peptides derived from a peptide scan through Uncharacterized protein HHRF7 (US32) of Human cytomegalovirus (HHV-5) for T cell assays
add to cart

Description

Product Code: PM-C-HCMV-1

Collection of 19 peptide pools (overlapping peptides scans, 15mers with 11 aa overlap) through 19 immuonodominant antigens of Human cytomegalovirus (HHV-5).
Amount: 2 aliquots of 19 peptide pools containing 1µg per peptide /tube
Purity: >70% (HPLC-MS)
Delivery Format: Freeze dried in micro tube rack with individual vials.
Application(s): T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response, Patient stratification, Qualification of immune responses
Indication(s)/Topic(s): Infection, Control, Cancer, TORCH, Infectious mononucleosis, CMV hepatitis, Retinitis, Colitis, Pneumonitis, Esophagitis, AIDS, Cancer chemotherapy, Transplantation
Delivery Time: 2-5 days

PepMix™ Peptide Pools
The use of complete protein-spanning mixtures of overlapping peptides (PepMix) is extremely efficient for immunostimulation of T-lymphocytes and diagnostic applications. In order to establish reliable and validated T-cell assays such as ELISPOT, appropriate positive and negative controls are essential. Selection of such controls helps to confirm proper functionality of the assay as well as viability of the cells used. In addition, high quality controls are most important to establish standardized assay protocols in clinical setups. Compared to commonly used controls like phytohemagglutinin (PHA) and concanavalin A (ConA) that stimulate T-cells as well as other cell types or full length antigens, synthetic peptide pools offer the advantage of a high batch-to-batch reproducibility, applicability of reliable chemical and biochemical QC/QA measures and shelf stability when stored as freeze dried aliquots.

Benefits of PepMix™
- Equivalent or better stimulation of CD4+ and CD8+ T-cell responses compared to whole protein antigens
- Simultaneous detection of CD4+ and CD8+ responses in a single sample
- Improved responses in stored blood and PBM cells compared to whole protein antigens
- More reliable as control than phytohemagglutinin (PHA) and concanavalin A (ConA)
- High-batch-to-batch reproducibility
- Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
- Prolonged shelf stability when stored freeze dried

References

References:
Read References with PepMix™ Peptide Pools - Infectious Diseases

Application Notes
"Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy"
Lam et al. (2015) Full text
"Peptide-stimulated Expansion of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell Transplantation"
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our "go-to" company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

Documentation

Properties

Related Products

PM-IE1
PepMix™ HCMVA (IE-1)
Positive Control Pool of 120 peptides derived from a peptide scan through 55 kDa immediate-early protein 1 (IE-1) of Human cytomegalovirus (HHV-5)
add to cart
PM-IE2
PepMix™ HCMVA (IE-2)
Positive Control Pool of 143 peptides derived from a peptide scan through 45 kDa immediate-early protein 2 (IE-2) of Human cytomegalovirus (HHV-5).
add to cart
PM-PP65-2
PepMix™ HCMVA (pp65) (>90%)
Positive Control Pool of 138 peptides derived from a peptide scan through 65 kDa phosphoprotein (pp65) of Human cytomegalovirus (HHV-5)
add to cart
PM-UL103
PepMix™ HCMVA (UL103)
Pool of 60 peptides derived from a peptide scan through Protein UL103 of Human cytomegalovirus (HHV-5) for T cell assays (e.g. ELISPOT)
add to cart
PM-UL151
PepMix™ HCMVA (UL151)
Pool of 82 peptides derived from a peptide scan through Orf UL151 of Human cytomegalovirus (HHV-5) for T cell assays (e.g. ELISPOT)
add to cart
PM-UL153
PepMix™ HCMVA (UL153)
Pool of 67 peptides derived from a peptide scan through Orf UL153 of Human cytomegalovirus (HHV-5) for T cell assays (e.g. ELISPOT)
add to cart
PM-UL28
PepMix™ HCMVA (UL28)
Pool of 92 peptides derived from a peptide scan through Uncharacterized protein UL28 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL36
PepMix™ HCMVA (UL36)
Pool of 117 peptides derived from a peptide scan through Uncharacterized protein UL36 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL40
PepMix™ HCMVA (UL40)
Pool of 53 peptides derived from a peptide scan through Uncharacterized protein UL40 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL48
PepMix™ HCMVA (UL48)_ 2 subpools
Pool of 2 x 281 peptides derived from a peptide scan through Deneddylase UL48 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL55
PepMix™ HCMVA (UL55)
Pool of 224 peptides derived from a peptide scan through Envelope glycoprotein B (UL55) of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL82
PepMix™ HCMVA (UL82)
Pool of 137 peptides derived from a peptide scan through 71 kDa phosphoprotein (UL82) of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL94
PepMix™ HCMVA (UL94)
Pool of 84 peptides derived from a peptide scan through Capsid-binding protein UL94 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-UL99
PepMix™ HCMVA (UL99)
Pool of 45 peptides derived from a peptide scan through Tegument protein UL99 of Human cytomegalovirus (HHV-5) for T cell assays (e.g. ELISPOT)
add to cart
PM-US24
PepMix™ HCMVA (US24)
Pool of 123 peptides derived from a peptide scan through Tegument protein US24 of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-US29
PepMix™ HCMVA (US29)
Pool of 113 peptides derived from a peptide scan through Uncharacterized protein HHRF4 (US29) of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-US3
PepMix™ HCMVA (US3)
Pool of 44 peptides derived from a peptide scan through Unique short US3 glycoprotein of Human cytomegalovirus (HHV-5) for T cell assays
add to cart
PM-US32
PepMix™ HCMVA (US32)
Pool of 43 peptides derived from a peptide scan through Uncharacterized protein HHRF7 (US32) of Human cytomegalovirus (HHV-5) for T cell assays
add to cart

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Contact us:

JPT Peptide Technologies GmbH
Volmerstrasse 5
12489 Berlin, Germany
Technical Support:
T: +49-30-6392-7878
X: +49-30-6392-7888
e-mail: peptide@jpt.com
USA & Canada:
T: 1.888.JPT.COM0 (1.888.578.2660)
X: 1.888.JPT.COM6 (1.888.578.2666)
e-mail: peptide@jpt.com