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PepMix™ VACV (Host range protein 2, MVA018L)

PepMix™ VACV (Host range protein 2, MVA018L)

PepMix™ VACV (Host range protein 2, MVA018L)
  
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Delivery in 2-5 days
288,00 €
288,00 €

Excluding tax
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PepMix™ VACV (Host range protein 2, MVA018L)

Product Code: PM-MVA-018L

Pool of 35 peptides derived from a peptide scan (15mers with 11 aa overlap) through Host range protein 2 (MVA018L) (Swiss-Prot ID: P68598) of Vaccinia virus (strain Ankara) for T cell assays.
Amount: 1 vial containing 15 nmol (appr. 25µg) per peptide
Purity: >70% (HPLC-MS)
Delivery Format: Freeze dried in amber type glass vial
Application(s): T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication(s)/Topic(s): Infection, Vaccination, Small Pox
Delivery Time: 2-5 days

PepMix™ Peptide Pools
The use of complete protein-spanning mixtures of overlapping peptides (PepMix) is extremely efficient for immunostimulation of T-lymphocytes and diagnostic applications. In order to establish reliable and validated T-cell assays such as ELISPOT, appropriate positive and negative controls are essential. Selection of such controls helps to confirm proper functionality of the assay as well as viability of the cells used. In addition, high quality controls are most important to establish standardized assay protocols in clinical setups. Compared to commonly used controls like phytohemagglutinin (PHA) and concanavalin A (ConA) that stimulate T-cells as well as other cell types or full length antigens, synthetic peptide pools offer the advantage of a high batch-to-batch reproducibility, applicability of reliable chemical and biochemical QC/QA measures and shelf stability when stored as freeze dried aliquots.

Benefits of PepMix™
- Equivalent or better stimulation of CD4+ and CD8+ T-cell responses compared to whole protein antigens
- Simultaneous detection of CD4+ and CD8+ responses in a single sample
- Improved responses in stored blood and PBM cells compared to whole protein antigens
- More reliable as control than phytohemagglutinin (PHA) and concanavalin A (ConA)
- High-batch-to-batch reproducibility
- Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
- Prolonged shelf stability when stored freeze dried

PepMix™ VACV (Host range protein 2, MVA018L)

References:
Read References with PepMix™ Peptide Pools - Infectious Diseases

Application Notes
"Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy"
Lam et al. (2015) Full text
"Peptide-stimulated Expansion of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell Transplantation"
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our "go-to" company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

PepMix™ VACV (Host range protein 2, MVA018L)

 
Code
Product Name
 
Price
Buy
PM-MVA-105L
PepMix™ VACV (Cell surface-binding protein, MVA105L)
Pool of 74 peptides derived from a peptide scan through Cell surface-binding protein (MVA105L) of Vaccinia virus (strain Ankara) for T cell assays
add to cart
PM-MVA-121L
PepMix™ VACV (Major core protein P4a, MVA 121L)_2 Subpools
Pool of 223 peptides (delivered in two subpools of 112 + 111 peptides) derived from a peptide scan through Major core protein P4a of Vaccinia virus
add to cart
PM-MVA-074R
PepMix™ VACV (MVA 074R)
Pool of 106 peptides derived from a peptide scan through Putative 49.8k protein (MVA 074R) of Vaccinia virus (strain Ankara) for T cell assays
add to cart
PM-MVA-093L
PepMix™ VACV (MVA093L)
Pool of 79 peptides derived from a peptide scan through IMV hep. binding surface protein (MVA093L) of Vaccinia virus (strain Ankara) for T cell assays
add to cart
PM-MVA-189R
PepMix™ VACV (MVA189R)
Pool of 45 peptides derived from a peptide scan through Putative 21.7k protein (MVA189R) of Vaccinia virus (strain Ankara) for T cell assays
add to cart
RT-MVA-105L
RepliTope™ VACV (Cell surface-binding protein, MVA105L)
Peptide microarray displaying 74 peptides derived from a peptide scan through Cell surface-binding protein (MVA105L) of Vaccinia virus (strain Ankara)
add to cart
RT-MVA-018L
RepliTope™ VACV (Host range protein 2, MVA018L)
Peptide microarray displaying 35 peptides derived from a peptide scan through Host range protein 2 (MVA018L) of Vaccinia virus (strain Ankara)
add to cart
RT-MVA-121L
RepliTope™ VACV (Major core protein P4a, MVA 121L)
Peptide microarray displaying 220 peptides derived from a peptide scan through Major core protein P4a (MVA 121L) of Vaccinia virus (strain Ankara)
add to cart
RT-MVA-074R
RepliTope™ VACV (MVA 074R)
Peptide microarray displaying 106 peptides derived from a peptide scan through Putative 49.8k protein (MVA 074R) of Vaccinia virus (strain Ankara)
add to cart
RT-MVA-093L
RepliTope™ VACV (MVA093L)
Peptide microarray displaying 79 peptides derived from a peptide scan through IMV hep. binding surface protein (MVA093L) of Vaccinia virus (strain Ankara)
add to cart
RT-MVA-189R
RepliTope™ VACV (MVA189R)
Peptide microarray displaying 45 peptides derived from a peptide scan through Putative 21.7k protein (MVA189R) of Vaccinia virus (strain Ankara)
add to cart

Description

Product Code: PM-MVA-018L

Pool of 35 peptides derived from a peptide scan (15mers with 11 aa overlap) through Host range protein 2 (MVA018L) (Swiss-Prot ID: P68598) of Vaccinia virus (strain Ankara) for T cell assays.
Amount: 1 vial containing 15 nmol (appr. 25µg) per peptide
Purity: >70% (HPLC-MS)
Delivery Format: Freeze dried in amber type glass vial
Application(s): T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication(s)/Topic(s): Infection, Vaccination, Small Pox
Delivery Time: 2-5 days

PepMix™ Peptide Pools
The use of complete protein-spanning mixtures of overlapping peptides (PepMix) is extremely efficient for immunostimulation of T-lymphocytes and diagnostic applications. In order to establish reliable and validated T-cell assays such as ELISPOT, appropriate positive and negative controls are essential. Selection of such controls helps to confirm proper functionality of the assay as well as viability of the cells used. In addition, high quality controls are most important to establish standardized assay protocols in clinical setups. Compared to commonly used controls like phytohemagglutinin (PHA) and concanavalin A (ConA) that stimulate T-cells as well as other cell types or full length antigens, synthetic peptide pools offer the advantage of a high batch-to-batch reproducibility, applicability of reliable chemical and biochemical QC/QA measures and shelf stability when stored as freeze dried aliquots.

Benefits of PepMix™
- Equivalent or better stimulation of CD4+ and CD8+ T-cell responses compared to whole protein antigens
- Simultaneous detection of CD4+ and CD8+ responses in a single sample
- Improved responses in stored blood and PBM cells compared to whole protein antigens
- More reliable as control than phytohemagglutinin (PHA) and concanavalin A (ConA)
- High-batch-to-batch reproducibility
- Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
- Prolonged shelf stability when stored freeze dried

References

References:
Read References with PepMix™ Peptide Pools - Infectious Diseases

Application Notes
"Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy"
Lam et al. (2015) Full text
"Peptide-stimulated Expansion of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell Transplantation"
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our "go-to" company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

Documentation

Properties

Related Products

PM-MVA-105L
PepMix™ VACV (Cell surface-binding protein, MVA105L)
Pool of 74 peptides derived from a peptide scan through Cell surface-binding protein (MVA105L) of Vaccinia virus (strain Ankara) for T cell assays
add to cart
PM-MVA-121L
PepMix™ VACV (Major core protein P4a, MVA 121L)_2 Subpools
Pool of 223 peptides (delivered in two subpools of 112 + 111 peptides) derived from a peptide scan through Major core protein P4a of Vaccinia virus
add to cart
PM-MVA-074R
PepMix™ VACV (MVA 074R)
Pool of 106 peptides derived from a peptide scan through Putative 49.8k protein (MVA 074R) of Vaccinia virus (strain Ankara) for T cell assays
add to cart
PM-MVA-093L
PepMix™ VACV (MVA093L)
Pool of 79 peptides derived from a peptide scan through IMV hep. binding surface protein (MVA093L) of Vaccinia virus (strain Ankara) for T cell assays
add to cart
PM-MVA-189R
PepMix™ VACV (MVA189R)
Pool of 45 peptides derived from a peptide scan through Putative 21.7k protein (MVA189R) of Vaccinia virus (strain Ankara) for T cell assays
add to cart
RT-MVA-105L
RepliTope™ VACV (Cell surface-binding protein, MVA105L)
Peptide microarray displaying 74 peptides derived from a peptide scan through Cell surface-binding protein (MVA105L) of Vaccinia virus (strain Ankara)
add to cart
RT-MVA-018L
RepliTope™ VACV (Host range protein 2, MVA018L)
Peptide microarray displaying 35 peptides derived from a peptide scan through Host range protein 2 (MVA018L) of Vaccinia virus (strain Ankara)
add to cart
RT-MVA-121L
RepliTope™ VACV (Major core protein P4a, MVA 121L)
Peptide microarray displaying 220 peptides derived from a peptide scan through Major core protein P4a (MVA 121L) of Vaccinia virus (strain Ankara)
add to cart
RT-MVA-074R
RepliTope™ VACV (MVA 074R)
Peptide microarray displaying 106 peptides derived from a peptide scan through Putative 49.8k protein (MVA 074R) of Vaccinia virus (strain Ankara)
add to cart
RT-MVA-093L
RepliTope™ VACV (MVA093L)
Peptide microarray displaying 79 peptides derived from a peptide scan through IMV hep. binding surface protein (MVA093L) of Vaccinia virus (strain Ankara)
add to cart
RT-MVA-189R
RepliTope™ VACV (MVA189R)
Peptide microarray displaying 45 peptides derived from a peptide scan through Putative 21.7k protein (MVA189R) of Vaccinia virus (strain Ankara)
add to cart

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All production is performed according to ISO 9001:2015 standards.

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Contact us:

JPT Peptide Technologies GmbH
Volmerstrasse 5
12489 Berlin, Germany
Technical Support:
T: +49-30-6392-7878
X: +49-30-6392-7888
e-mail: peptide@jpt.com
USA & Canada:
T: 1.888.JPT.COM0 (1.888.578.2660)
X: 1.888.JPT.COM6 (1.888.578.2666)
e-mail: peptide@jpt.com