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PepMix™ Human (Histone H1.2)

PepMix™ Human (Histone H1.2)

PepMix™ Human (Histone H1.2)
  
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Delivery in 2-5 days
317,00 €
317,00 €

Excluding tax
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PepMix™ Human (Histone H1.2)

Product Code: PM-H1.2

Pool of 51 peptides derived from a peptide scan (15mers with 11 aa overlap) through Histone H1.2 (Swiss-Prot ID: P16403) of Homo sapiens (Human) for T cell assays (antigen specific T-cell stimulation).
Amount: 1 vial containing 15 nmol (appr. 25µg) per peptide
Purity: >70% (HPLC-MS)
Delivery Format: Freeze dried in amber type glass vial
Application(s): T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication(s)/Topic(s): Cancer
Delivery Time: 2-5 days

PepMixes™ Peptide Pools
The use of complete protein-spanning mixtures of overlapping peptides (PepMix™) is extremely efficient for immunostimulation of T-lymphocytes and diagnostic applications. In order to establish reliable and validated T-cell assays such as ELISPOT, appropriate positive and negative controls are essential. Selection of such controls helps to confirm proper functionality of the assay as well as viability of the cells used. In addition, high quality controls are most important to establish standardized assay protocols in clinical setups. Compared to commonly used controls like phytohemagglutinin (PHA) and concanavalin A (ConA) that stimulate T-cells as well as other cell types or full length antigens, synthetic peptide pools offer the advantage of a high batch-to-batch reproducibility, applicability of reliable chemical and biochemical QC/QA measures and shelf stability when stored as freeze dried aliquots.

Benefits of PepMix™
- Equivalent or better stimulation of CD4+ and CD8+ T-cell responses compared to whole protein antigens
- Simultaneous detection of CD4+ and CD8+ responses in a single sample
- Improved responses in stored blood and PBM cells compared to whole protein antigens
- More reliable as control than phytohemagglutinin (PHA) and concanavalin A (ConA)
- High-batch-to-batch reproducibility
- Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
- Prolonged shelf stability when stored freeze dried

PepMix™ Human (Histone H1.2)

References:
Read References with PepMix™ Peptide Pools - Tumor Associated Antigens

Application Notes
"Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy"
Lam et al. (2015) Full text
"Peptide-stimulated Expansion of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell Transplantation"
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our "go-to" company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

PepMix™ Human (Histone H1.2)

 
Code
Product Name
 
Price
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PM-WRK
PepMix™ Arabidopsis (WRKY47)
Pool of 120 peptides derived from a peptide scan through Probable WRKY transcription factor 47 of Arabidopsis thaliana (Mouse-ear cress)
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PM-CYC_B1
PepMix™ Human (Cyclin-B1)
Pool of 106 peptides derived from a peptide scan through G2/mitotic-specific cyclin-B1 of Homo sapiens (Human) for T cell assays (e.g. ELISPOT)
add to cart
PM-H4
PepMix™ Human (Histone H4)
Pool of 23 peptides derived from a peptide scan through Histone H4 of Homo sapiens (Human) for T cell assays (e.g. antigen specific T-cell stimulation)
add to cart
PM-p53
PepMix™ Human (P53)
Pool of 96 peptides derived from a peptide scan through Cellular tumor antigen p53 of Homo sapiens (Human) for T cell assays (e.g. ELISPOT)
add to cart
PM-TRP-2
PepMix™ Human (Tyrosinase-related protein 2)
Pool of 127 peptides derived from a peptide scan through L-dopachrome tautomerase (Tyrosinase-related protein 2) of Homo sapiens (Human)
add to cart
PM-Survivin
PepMix™ Human (Survivin)
Pool of 33 peptides derived from a peptide scan through Baculoviral IAP repeat-containing protein 5 (Survivin) of Human for T cell assays
add to cart
RT-WRK
RepliTope™ Arabidopsis (WRKY47)
Peptide microarray displaying 120 peptides derived from a peptide scan through Probable WRKY transcription factor 47 of Arabidopsis thaliana (Mouse-ear cress)
add to cart
RT-H1
RepliTope™ Human (Histone H1.2)
Peptide microarray displaying 51 peptides derived from a peptide scan through Histone H1.2 of Homo sapiens (Human)
add to cart
RT-H4
RepliTope™ Human (Histone H4)
Peptide microarray displaying 23 peptides derived from a peptide scan through Histone H4 of Homo sapiens (Human)
add to cart
RT-p53
RepliTope™ Human (P53)
Peptide microarray displaying 96 peptides derived from a peptide scan through Cellular tumor antigen p53 of Homo sapiens (Human)
add to cart
RT-TRP-2
RepliTope™ Human (Tyrosinase-related protein 2)
Peptide microarray displaying 127 peptides derived from a peptide scan through L-dopachrome tautomerase (Tyrosinase-related protein 2) of Homo sapiens (Human)
add to cart
RT-Survivin
RepliTope™ Human (Survivin)
Peptide microarray displaying 33 peptides derived from a peptide scan through Baculoviral IAP repeat-containing protein 5 (Survivin) of Homo sapiens (Human)
add to cart

Description

Product Code: PM-H1.2

Pool of 51 peptides derived from a peptide scan (15mers with 11 aa overlap) through Histone H1.2 (Swiss-Prot ID: P16403) of Homo sapiens (Human) for T cell assays (antigen specific T-cell stimulation).
Amount: 1 vial containing 15 nmol (appr. 25µg) per peptide
Purity: >70% (HPLC-MS)
Delivery Format: Freeze dried in amber type glass vial
Application(s): T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication(s)/Topic(s): Cancer
Delivery Time: 2-5 days

PepMixes™ Peptide Pools
The use of complete protein-spanning mixtures of overlapping peptides (PepMix™) is extremely efficient for immunostimulation of T-lymphocytes and diagnostic applications. In order to establish reliable and validated T-cell assays such as ELISPOT, appropriate positive and negative controls are essential. Selection of such controls helps to confirm proper functionality of the assay as well as viability of the cells used. In addition, high quality controls are most important to establish standardized assay protocols in clinical setups. Compared to commonly used controls like phytohemagglutinin (PHA) and concanavalin A (ConA) that stimulate T-cells as well as other cell types or full length antigens, synthetic peptide pools offer the advantage of a high batch-to-batch reproducibility, applicability of reliable chemical and biochemical QC/QA measures and shelf stability when stored as freeze dried aliquots.

Benefits of PepMix™
- Equivalent or better stimulation of CD4+ and CD8+ T-cell responses compared to whole protein antigens
- Simultaneous detection of CD4+ and CD8+ responses in a single sample
- Improved responses in stored blood and PBM cells compared to whole protein antigens
- More reliable as control than phytohemagglutinin (PHA) and concanavalin A (ConA)
- High-batch-to-batch reproducibility
- Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
- Prolonged shelf stability when stored freeze dried

References

References:
Read References with PepMix™ Peptide Pools - Tumor Associated Antigens

Application Notes
"Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy"
Lam et al. (2015) Full text
"Peptide-stimulated Expansion of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell Transplantation"
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our "go-to" company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

Documentation

Properties

Related Products

PM-WRK
PepMix™ Arabidopsis (WRKY47)
Pool of 120 peptides derived from a peptide scan through Probable WRKY transcription factor 47 of Arabidopsis thaliana (Mouse-ear cress)
add to cart
PM-CYC_B1
PepMix™ Human (Cyclin-B1)
Pool of 106 peptides derived from a peptide scan through G2/mitotic-specific cyclin-B1 of Homo sapiens (Human) for T cell assays (e.g. ELISPOT)
add to cart
PM-H4
PepMix™ Human (Histone H4)
Pool of 23 peptides derived from a peptide scan through Histone H4 of Homo sapiens (Human) for T cell assays (e.g. antigen specific T-cell stimulation)
add to cart
PM-p53
PepMix™ Human (P53)
Pool of 96 peptides derived from a peptide scan through Cellular tumor antigen p53 of Homo sapiens (Human) for T cell assays (e.g. ELISPOT)
add to cart
PM-TRP-2
PepMix™ Human (Tyrosinase-related protein 2)
Pool of 127 peptides derived from a peptide scan through L-dopachrome tautomerase (Tyrosinase-related protein 2) of Homo sapiens (Human)
add to cart
PM-Survivin
PepMix™ Human (Survivin)
Pool of 33 peptides derived from a peptide scan through Baculoviral IAP repeat-containing protein 5 (Survivin) of Human for T cell assays
add to cart
RT-WRK
RepliTope™ Arabidopsis (WRKY47)
Peptide microarray displaying 120 peptides derived from a peptide scan through Probable WRKY transcription factor 47 of Arabidopsis thaliana (Mouse-ear cress)
add to cart
RT-H1
RepliTope™ Human (Histone H1.2)
Peptide microarray displaying 51 peptides derived from a peptide scan through Histone H1.2 of Homo sapiens (Human)
add to cart
RT-H4
RepliTope™ Human (Histone H4)
Peptide microarray displaying 23 peptides derived from a peptide scan through Histone H4 of Homo sapiens (Human)
add to cart
RT-p53
RepliTope™ Human (P53)
Peptide microarray displaying 96 peptides derived from a peptide scan through Cellular tumor antigen p53 of Homo sapiens (Human)
add to cart
RT-TRP-2
RepliTope™ Human (Tyrosinase-related protein 2)
Peptide microarray displaying 127 peptides derived from a peptide scan through L-dopachrome tautomerase (Tyrosinase-related protein 2) of Homo sapiens (Human)
add to cart
RT-Survivin
RepliTope™ Human (Survivin)
Peptide microarray displaying 33 peptides derived from a peptide scan through Baculoviral IAP repeat-containing protein 5 (Survivin) of Homo sapiens (Human)
add to cart

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JPT Peptide Technologies GmbH
Volmerstrasse 5
12489 Berlin, Germany
Technical Support:
T: +49-30-6392-7878
X: +49-30-6392-7888
e-mail: peptide@jpt.com
USA & Canada:
T: 1.888.JPT.COM0 (1.888.578.2660)
X: 1.888.JPT.COM6 (1.888.578.2666)
e-mail: peptide@jpt.com