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Protransduzin™ RUO (2mg)
Protransduzin™ RUO (2mg)
Protransduzin™ RUO (2mg)
Product Code: TE-PTDB-2
Highly efficient transduction enhancer for viral gene transfer in preclinical research applications.
Amount: 2mg Protransduzin™
Grade: For research use only (RUO)
Delivery Format: Lyophilized in glass vials
Application(s): Cell therapy, Transduction
Indication(s)/Topic(s): Cancer, Gene therapy
Delivery Time: 2-5 days
Transduction Enhancer Protransduzin™
Protransduzin™ increases retro- and lentiviral gene transfer in preclinical and clinical applications, such as bioproduction, ex vivo gene therapy and CAR-T cell therapy. Low transduction efficiencies of retro- and lentiviral vectors pose a significant problem. However, simply increasing viral amount to boost transduction may lead to toxic effects and common transduction enhancers (e.g. recombinant fibronectin) require time consuming protocols. In contrast, Protransduzin™ (PTD) enhances transduction by bridging viruses to the cell surface in one step. PTD assembles into nanofibrils which efficiently bind to viral particles in the surrounding medium. The virus-loaded fibrils link with cellular membranes (receptor independently), increasing the number of viral particles at the cell surface. The subsequent transduction is enhanced.
Benefits of Protransduzin™
- Easy one-step protocol saves time and money
- No coating or cell transfer required minimizing risk of contamination
- Works with many cell types, including T cells, macrophages and hematopoietic stem cells
- At least as effective as commonly used transduction enhancers
Description
Product Code: TE-PTDB-2
Highly efficient transduction enhancer for viral gene transfer in preclinical research applications.
Amount: 2mg Protransduzin™
Grade: For research use only (RUO)
Delivery Format: Lyophilized in glass vials
Application(s): Cell therapy, Transduction
Indication(s)/Topic(s): Cancer, Gene therapy
Delivery Time: 2-5 days
Transduction Enhancer Protransduzin™
Protransduzin™ increases retro- and lentiviral gene transfer in preclinical and clinical applications, such as bioproduction, ex vivo gene therapy and CAR-T cell therapy. Low transduction efficiencies of retro- and lentiviral vectors pose a significant problem. However, simply increasing viral amount to boost transduction may lead to toxic effects and common transduction enhancers (e.g. recombinant fibronectin) require time consuming protocols. In contrast, Protransduzin™ (PTD) enhances transduction by bridging viruses to the cell surface in one step. PTD assembles into nanofibrils which efficiently bind to viral particles in the surrounding medium. The virus-loaded fibrils link with cellular membranes (receptor independently), increasing the number of viral particles at the cell surface. The subsequent transduction is enhanced.
Benefits of Protransduzin™
- Easy one-step protocol saves time and money
- No coating or cell transfer required minimizing risk of contamination
- Works with many cell types, including T cells, macrophages and hematopoietic stem cells
- At least as effective as commonly used transduction enhancers
References
Documentation
Properties
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