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Protransduzin™ RUO (2mg)

  
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155,00 €
155,00 €

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Protransduzin™ RUO (2mg)

Product Code: TE-PTDB-2

Highly efficient transduction enhancer for viral gene transfer in preclinical research applications.
Amount: 2mg Protransduzin™
Grade: For research use only (RUO)
Delivery Format: Lyophilized in glass vials
Application(s): Cell therapy, Transduction
Indication(s)/Topic(s): Cancer, Gene therapy
Delivery Time: 2-5 days

Transduction Enhancer Protransduzin™
Protransduzin™ increases retro- and lentiviral gene transfer in preclinical and clinical applications, such as bioproduction, ex vivo gene therapy and CAR-T cell therapy. Low transduction efficiencies of retro- and lentiviral vectors pose a significant problem. However, simply increasing viral amount to boost transduction may lead to toxic effects and common transduction enhancers (e.g. recombinant fibronectin) require time consuming protocols. In contrast, Protransduzin™ (PTD) enhances transduction by bridging viruses to the cell surface in one step. PTD assembles into nanofibrils which efficiently bind to viral particles in the surrounding medium. The virus-loaded fibrils link with cellular membranes (receptor independently), increasing the number of viral particles at the cell surface. The subsequent transduction is enhanced.

Benefits of Protransduzin™
- Easy one-step protocol saves time and money
- No coating or cell transfer required minimizing risk of contamination
- Works with many cell types, including T cells, macrophages and hematopoietic stem cells
- At least as effective as commonly used transduction enhancers

Description

Product Code: TE-PTDB-2

Highly efficient transduction enhancer for viral gene transfer in preclinical research applications.
Amount: 2mg Protransduzin™
Grade: For research use only (RUO)
Delivery Format: Lyophilized in glass vials
Application(s): Cell therapy, Transduction
Indication(s)/Topic(s): Cancer, Gene therapy
Delivery Time: 2-5 days

Transduction Enhancer Protransduzin™
Protransduzin™ increases retro- and lentiviral gene transfer in preclinical and clinical applications, such as bioproduction, ex vivo gene therapy and CAR-T cell therapy. Low transduction efficiencies of retro- and lentiviral vectors pose a significant problem. However, simply increasing viral amount to boost transduction may lead to toxic effects and common transduction enhancers (e.g. recombinant fibronectin) require time consuming protocols. In contrast, Protransduzin™ (PTD) enhances transduction by bridging viruses to the cell surface in one step. PTD assembles into nanofibrils which efficiently bind to viral particles in the surrounding medium. The virus-loaded fibrils link with cellular membranes (receptor independently), increasing the number of viral particles at the cell surface. The subsequent transduction is enhanced.

Benefits of Protransduzin™
- Easy one-step protocol saves time and money
- No coating or cell transfer required minimizing risk of contamination
- Works with many cell types, including T cells, macrophages and hematopoietic stem cells
- At least as effective as commonly used transduction enhancers

References

Documentation

Properties

Quality Assurance

All production is performed according to ISO 9001:2015 standards.

ISO 9001

 
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JPT Peptide Technologies GmbH
Volmerstrasse 5
12489 Berlin, Germany
Technical Support:
T: +49-30-6392-7878
X: +49-30-6392-7888
e-mail: peptide@jpt.com
USA & Canada:
T: 1.888.JPT.COM0 (1.888.578.2660)
X: 1.888.JPT.COM6 (1.888.578.2666)
e-mail: peptide@jpt.com