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MHC I Dextramer H-2 Kb (STYTFVRT)
MHC I Dextramer H-2 Kb (STYTFVRT)
MHC I Dextramer H-2 Kb (STYTFVRT)
Product Code: MHC3442
Fluorescent MHC Dextramers® for sensitive and specific detection of antigen-specific T cells using flow cytometry. Available in three colors (PE, APC, and FITC), covering human, mouse and monkey alleles.
Amount: 1 vial containing 50 /150 / 500 or 1000 tests
Application(s): Cellular immune response, Immune monitoring, T-cell assays, Immunohistochemistry
Indication(s)/Topic(s): AIDS, Autoimmune disease, Breast cancer, Cancer, Cancer chemotherapy, Control, Diabetes, Graft-vs-host disease, Hematopoetic system, Hepatitis, Infection, Malaria, Malignant genital cancers, Melanoma, Prostate cancer, Testis/ovary cancer, Tuberculosis, Transplantation, Vaccination, Wilms tumor 1
Delivery Time: 10-12 days
MHC I Dextramers®
MHC Multimers such as Dextramers® are used for detection, enumeration and isolation of antigen-specific T cells in fluid cell samples (PBMC, blood) by flow cytometry, and can be applied to tissue sections to visualize antigen-specific T cells in situ.Fields of application are vaccine and immunotherapeutic development, clinical trials, immune monitoring of transplantation patients, patients with HIV and many more. The MHC class I Dextramers® combine a dextran polymer backbone with a high number of MHC and fluorochrome molecules. This enhances their staining intensity, thereby increasing resolution and the signal-to-noise ratio with minimal background staining. In addition, the polymer backbone stabilizes the MHC-peptide complexes and fluorochromes.
Benefits of MHC I Dextramers®
- More MHC molecules and more fluorochromes than conventional MHC multimers (e.g. tetramers)
- Higher sensitivity (important for low affinity epitopes as commonly found in cancer & autoimmune disease)
- Very stable
- Custom-made Dextramers® available upon request
MHC I Dextramer H-2 Kb (STYTFVRT)
References:
Read References with MHC Multimers
MHC I Dextramer H-2 Kb (STYTFVRT)
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Pool of 43 peptides derived from a peptide scan through Cancer/testis antigen 1 (NY-ESO-1) of Homo sapiens for T cell assays (e.g. ELISPOT)
Multimer collection of 6 carefully selected melanoma specific antigen Dextramers and one control. Two aliquots / antigen with different fluorescent labels (PE and APC) are deli...
Multimer collection of 4 selected virus (CMV, EBV, BKV & Influenza) antigen Dextramers and one control. The set comes with APC label
Description
Product Code: MHC3442
Fluorescent MHC Dextramers® for sensitive and specific detection of antigen-specific T cells using flow cytometry. Available in three colors (PE, APC, and FITC), covering human, mouse and monkey alleles.
Amount: 1 vial containing 50 /150 / 500 or 1000 tests
Application(s): Cellular immune response, Immune monitoring, T-cell assays, Immunohistochemistry
Indication(s)/Topic(s): AIDS, Autoimmune disease, Breast cancer, Cancer, Cancer chemotherapy, Control, Diabetes, Graft-vs-host disease, Hematopoetic system, Hepatitis, Infection, Malaria, Malignant genital cancers, Melanoma, Prostate cancer, Testis/ovary cancer, Tuberculosis, Transplantation, Vaccination, Wilms tumor 1
Delivery Time: 10-12 days
MHC I Dextramers®
MHC Multimers such as Dextramers® are used for detection, enumeration and isolation of antigen-specific T cells in fluid cell samples (PBMC, blood) by flow cytometry, and can be applied to tissue sections to visualize antigen-specific T cells in situ.Fields of application are vaccine and immunotherapeutic development, clinical trials, immune monitoring of transplantation patients, patients with HIV and many more. The MHC class I Dextramers® combine a dextran polymer backbone with a high number of MHC and fluorochrome molecules. This enhances their staining intensity, thereby increasing resolution and the signal-to-noise ratio with minimal background staining. In addition, the polymer backbone stabilizes the MHC-peptide complexes and fluorochromes.
Benefits of MHC I Dextramers®
- More MHC molecules and more fluorochromes than conventional MHC multimers (e.g. tetramers)
- Higher sensitivity (important for low affinity epitopes as commonly found in cancer & autoimmune disease)
- Very stable
- Custom-made Dextramers® available upon request
References
References:
Read References with MHC Multimers
Properties
Related Products
Pool of 43 peptides derived from a peptide scan through Cancer/testis antigen 1 (NY-ESO-1) of Homo sapiens for T cell assays (e.g. ELISPOT)
Multimer collection of 6 carefully selected melanoma specific antigen Dextramers and one control. Two aliquots / antigen with different fluorescent labels (PE and APC) are deli...
Multimer collection of 4 selected virus (CMV, EBV, BKV & Influenza) antigen Dextramers and one control. The set comes with APC label
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