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Melanoma Dextramer Collection 1

Melanoma Dextramer Collection 1
  
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Delivery in 10-12 days
6.199,00 €
6.199,00 €

Excluding tax
prices do not include tax. For shipment within Germany 19% MwSt will be included at checkout and in the invoice. For shipment within EU-countries you will need to provide the valid VAT number. International customers should note that all duties, import fees, and taxes are to be paid by the customer
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Combine this product with our corresponding Human MAGE-A3 Products: Dextramers®, PepMix™ Peptide Pools, Antigen Peptides, Universal T Cell Assay Standard TERS™ Kit and RepliTope™ Peptide Microarrays.

Melanoma Dextramer Collection 1

Product Code: RX01

Collection of 6 carefully selected melanoma specific MHC I Dextramers (+ 1 control), for sensitive and specific detection of antigen-specific T cells using flow cytometry. Delivery of two aliquots/antigen with different fluorescent labels (PE and APC).
Amount: 14 x 25 tests
Application(s): Cellular immune response, Immune monitoring, T-cell assays, Determination of pre-existing and induced immunity
Indication(s)/Topic(s): Cancer, Cancer chemotherapy, Control, Melanoma, Vaccination
Delivery Time: 10-12 days

MHC I Dextramer Collections
MHC class I Dextramers combine a dextran polymer backbone with a high number of MHC and fluorochrome molecules providing mulitple binding domains for antigen-specific T cell receptor binding. This enhances their staining intensity and increases resolution as well as signal-to-noise ratio with minimal background staining. In addition, the dextran backbone stabilizes the MHC-peptide complexes and fluorochromes. The Melanoma set is useful for enumeration of melanoma-specific CD8+ T cells, to detect or isolate melanoma-specific CD8+ T cells, e.g. during cancer vaccine and immunotherapeutic development. Each Dextramer is provided both as a PE- and APC conjugate, allowing for double staining of each cell sample to better resolve positive from negative cell populations.

The following 7 Dextramers are provided each with APC and PE label

Dextramer: HLA-A*0201 / ELAGIGILTV - Antigen: MART-1
Dextramer: HLA-A*0201 / SLLMWITQV - Antigen: NY-ESO-1
Dextramer: HLA-A*0201 / KVAELVHFL - Antigen: MAGE-A3
Dextramer: HLA-A*0201 / YMDGTMSQV - Antigen: Tyrosinase
Dextramer: HLA-A*0201 / IMDQVPFSV - Antigen: gp100
Dextramer: HLA-A*0201 / KVLEYVIKV - Antigen: MAGE-A1
Dextramer: HLA-A*0201 / Negative Control

Benefits of MHC I Dextramer® Collections
- More MHC molecules and more fluorochromes than conventional MHC multimers
- Higher sensitivity (important for low-affinity epitopes as commonly found in cancer & autoimmune disease)
- High stability
- Custom-made Dextramer available upon request

Melanoma Dextramer Collection 1

References:
Read References with MHC Multimers

Description

Product Code: RX01

Collection of 6 carefully selected melanoma specific MHC I Dextramers (+ 1 control), for sensitive and specific detection of antigen-specific T cells using flow cytometry. Delivery of two aliquots/antigen with different fluorescent labels (PE and APC).
Amount: 14 x 25 tests
Application(s): Cellular immune response, Immune monitoring, T-cell assays, Determination of pre-existing and induced immunity
Indication(s)/Topic(s): Cancer, Cancer chemotherapy, Control, Melanoma, Vaccination
Delivery Time: 10-12 days

MHC I Dextramer Collections
MHC class I Dextramers combine a dextran polymer backbone with a high number of MHC and fluorochrome molecules providing mulitple binding domains for antigen-specific T cell receptor binding. This enhances their staining intensity and increases resolution as well as signal-to-noise ratio with minimal background staining. In addition, the dextran backbone stabilizes the MHC-peptide complexes and fluorochromes. The Melanoma set is useful for enumeration of melanoma-specific CD8+ T cells, to detect or isolate melanoma-specific CD8+ T cells, e.g. during cancer vaccine and immunotherapeutic development. Each Dextramer is provided both as a PE- and APC conjugate, allowing for double staining of each cell sample to better resolve positive from negative cell populations.

The following 7 Dextramers are provided each with APC and PE label

Dextramer: HLA-A*0201 / ELAGIGILTV - Antigen: MART-1
Dextramer: HLA-A*0201 / SLLMWITQV - Antigen: NY-ESO-1
Dextramer: HLA-A*0201 / KVAELVHFL - Antigen: MAGE-A3
Dextramer: HLA-A*0201 / YMDGTMSQV - Antigen: Tyrosinase
Dextramer: HLA-A*0201 / IMDQVPFSV - Antigen: gp100
Dextramer: HLA-A*0201 / KVLEYVIKV - Antigen: MAGE-A1
Dextramer: HLA-A*0201 / Negative Control

Benefits of MHC I Dextramer® Collections
- More MHC molecules and more fluorochromes than conventional MHC multimers
- Higher sensitivity (important for low-affinity epitopes as commonly found in cancer & autoimmune disease)
- High stability
- Custom-made Dextramer available upon request

References

References:
Read References with MHC Multimers

Properties

Quality Assurance

All production is performed according to ISO 9001:2015 standards.

ISO 9001

 
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JPT Peptide Technologies GmbH
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12489 Berlin, Germany
Technical Support:
T: +49-30-6392-7878
X: +49-30-6392-7888
e-mail: peptide@jpt.com
USA & Canada:
T: 1.888.JPT.COM0 (1.888.578.2660)
X: 1.888.JPT.COM6 (1.888.578.2666)
e-mail: peptide@jpt.com